B Cell Modulation
The Chapman Lab focuses on developing next-generation, B cell–targeted precision therapeutics and uncovering the molecular mechanisms that drive humoral immunity and autoimmunity. By integrating protein engineering, bioorthogonal chemistry, and immunological approaches, we design innovative therapies that selectively engage B cells to promote more effective treatments and improve health outcomes.
Antigen-Drug Conjugate and Antigen Engineering
Improving antigen-specific depletion through optimized drug conjugates and biomimetic. Vaccine design for more durable immunity
How can we improve the selectivity, toxicity, or stimulating properties of targeted therapies and vaccines using rational design of all components?
B Cell Modulation using Targeted Therapeutics
Developing innovative treatments to improve vaccines or eliminate auto-reactive B cells.
Can we develop precision medicines to remodel B cell immunity or overcome antigen-specific autoimmunity?
Germinal Center Biology
Investigating mechanisms of B cell evolution after infection or vaccination.
How do germinal center dynamics in complex activation scenarios impact immunity? How might we bolster GC kinetics and antigen trafficking to design better vaccines?